Increase in Clostridium difficile–related Mortality Rates, United States, 1999–2004
نویسندگان
چکیده
Reported mortality rates from Clostridium difficile disease in the United States increased from 5.7 per million population in 1999 to 23.7 per million in 2004. Increased rates may be due to emergence of a highly virulent strain of C. difficile. Rates were higher for whites than for other racial/ethnic groups.
منابع مشابه
Increase in Adult Clostridium difficile–related Hospitalizations and Case-Fatality Rate, United States, 2000–2005
Virulence of and deaths from Clostridium difficile-associated disease (CDAD) are on the rise in the United States. The incidence of adult CDAD hospitalizations doubled from 5.5 cases per 10,000 population in 2000 to 11.2 in 2005, and the CDAD-related age-adjusted case-fatality rate rose from 1.2% in 2000 to 2.2% in 2004.
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Clostridium difficile infection (CDI) causes antibiotic-associated diarrhea and pseudomembranous colitis. Hypervirulent strains of the pathogen, which are responsible for increased morbidity and mortality of CDI, produce the binary actin-ADP ribosylating toxin Clostridium difficile transferase (CDT) in addition to the Rho-glucosylating toxins A and B. CDT depolymerizes the actin cytoskeleton, i...
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OBJECTIVE To evaluate changes in the epidemiological features of Clostridium difficile colitis in hospitalized patients in the United States (C difficile is a common cause of nosocomial diarrhea that has been shown to be increasing in virulence in Canada and across Europe). DESIGN Cohort analysis of all patients with C difficile colitis in the Nationwide Inpatient Sample. SETTING Population...
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عنوان ژورنال:
دوره 13 شماره
صفحات -
تاریخ انتشار 2007